Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.66 |
| ▸ | MME | P08473 | 2/20 | 0.66 |
| ▸ | CTSA | P10619 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TPH1 | P17752 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2876316 | 0.99 | MMEL1 (0.64) | MMEL1MMECTSAALDH1A1HPGD | |
| SCHEMBL12974475 | 0.86 | MME (0.53) | MMEL1MMECTSAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL17667997 | 0.85 | MME (0.54) | MMEL1MMECTSAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1912556 | 0.85 | MMEL1 (0.64) | MMEL1MMECTSATPH1 | |
| Hydrochloric Acid SCHEMBL1912657 | 0.83 | MMEL1 (0.61) | MMEL1MME | |
| SCHEMBL7446938 | 0.83 | MME (0.63) | MMEL1MME | |
| SCHEMBL2875557 | 0.83 | MME (0.57) | MMEL1MME | |
| SCHEMBL15963489 | 0.83 | MME (0.57) | MMEL1MME | |
| Hydrochloric Acid SCHEMBL1912641 | 0.81 | MME (0.56) | MMEL1MME | |
| SCHEMBL2870419 | 0.79 | MME (1.00) | MMEL1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594557-B1 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2016-08-10 | — | — | EP | disclosed |