Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | GRM5 | P41594 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GCK | P35557 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | KDM4B | O94953 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795585 | 0.84 | GRM5 (0.52) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1795424 | 0.84 | NPC1 (0.70) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL12258301 | 0.84 | NPC1 (0.71) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1796144 | 0.83 | GRM5 (0.58) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1794974 | 0.83 | GRM5 (0.53) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL29074201 | 0.82 | NPC1 (0.60) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1793529 | 0.81 | NPC1 (0.56) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1797781 | 0.81 | SMARCA2 (0.61) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1798244 | 0.80 | GRM5 (0.60) | NPC1RAB9AGRM5KDM4EGAA | |
| SCHEMBL1796021 | 0.80 | GRM5 (0.54) | NPC1RAB9AGRM5KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| US-7951824-B2 | 4-aryl-pyridine-2-carboxyamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |