Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367345 | 0.90 | ROCK1 (0.39) | ROCK1MKNK1MKNK2HRH3ROCK2 | |
| SCHEMBL4367350 | 0.90 | ROCK1 (0.39) | ROCK1MKNK1MKNK2HRH3ROCK2 | |
| SCHEMBL3388421 | 0.83 | NOS3 (0.37) | ROCK1ROCK2KCNH2TNK2 | |
| SCHEMBL12540028 | 0.79 | ESR2 (0.35) | MEN1KMT2A | |
| SCHEMBL12540026 | 0.79 | ESR2 (0.35) | MEN1KMT2A | |
| SCHEMBL4142576 | 0.76 | MKNK1 (0.42) | ROCK1MKNK1MKNK2HRH3TLR9 | |
| SCHEMBL30769910 | 0.75 | TLR9 (0.43) | ROCK1MKNK1MKNK2HRH3TLR9 | |
| SCHEMBL2244757 | 0.75 | TLR9 (0.43) | ROCK1MKNK1MKNK2HRH3TLR9 | |
| Hydrochloric Acid SCHEMBL27035336 | 0.74 | HTR2C (0.42) | ROCK1MKNK1MKNK2HRH3TLR9 | |
| SCHEMBL28076460 | 0.72 | HRH4 (0.41) | ROCK1MKNK1MKNK2HRH3TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107567445-A | It can be used as 2 phenyl 3H imidazos [4,5 B] pyridine derivates of mammal EGFR-TK ROR1 activities inhibitor | 坎塞拉有限公司 | 2018-01-09 | — | — | CN | disclosed |
| WO-2016124553-A1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2016-08-11 | — | — | WO | disclosed |