Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | JAK1 | P23458 | 2/20 | 0.58 |
| ▸ | TYK2 | P29597 | 2/20 | 0.58 |
| ▸ | JAK3 | P52333 | 2/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | TBK1 | Q9UHD2 | 15/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 13/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27228439 | 0.85 | JAK2 (0.54) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL23281920 | 0.84 | JAK2 (0.53) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL29713621 | 0.81 | JAK2 (0.57) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL23275803 | 0.81 | JAK2 (0.57) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL23281915 | 0.81 | JAK2 (0.59) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL459048 | 0.81 | TBK1 (0.73) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL17387774 | 0.80 | JAK2 (0.55) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL15974620 | 0.80 | MAP3K14 (0.53) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL15974622 | 0.80 | MAP3K14 (0.53) | MAP3K14JAK2JAK1TYK2JAK3 | |
| SCHEMBL17403594 | 0.79 | MAP3K14 (0.54) | MAP3K14JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958910-B1 | PYRIMIDINE COMPOUNDS USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY IKKE AND/OR TBK1 MECHANISMS | DOMAINEX LTD (GB) | 2016-08-03 | — | — | EP | disclosed |