Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.36 |
| ▸ | LPO | P22079 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17970510 | 0.80 | EZH2 (0.42) | KDM4EPKMEZH2EEDRBBP4 | |
| SCHEMBL17970524 | 0.77 | EED (0.45) | ALDH1A1HPGDKDM4EHSD17B10PKM | |
| SCHEMBL1695068 | 0.75 | TSHR (0.42) | ALDH1A1HPGDKDM4EGLAGAA | |
| SCHEMBL17970490 | 0.71 | EZH2 (0.35) | ALDH1A1HPGDKDM4EGLAGAA | |
| SCHEMBL18560159 | 0.71 | TSHR (0.47) | ALDH1A1HPGDKDM4EGLAGAA | |
| SCHEMBL1694783 | 0.68 | KDM4E (0.64) | ALDH1A1HPGDKDM4EGLAGAA | |
| SCHEMBL21156095 | 0.68 | EZH2 (0.41) | ALDH1A1HPGDKDM4EHSD17B10PKM | |
| SCHEMBL17970362 | 0.67 | KDM4E (0.35) | KDM4EGAAPKMEZH2EED | |
| Trifluoroacetic Acid SCHEMBL1695078 | 0.66 | KDM4E (0.41) | ALDH1A1HPGDKDM4EGLAGAA | |
| SCHEMBL12570733 | 0.63 | MPO (0.44) | ALDH1A1HPGDKDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773754-B1 | Compounds for use in the treatment of T-cell mediated diseases | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-08-03 | — | — | EP | disclosed |