Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19765245 | 0.76 | ALDH1A1 (0.36) | CYP2C19CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL29211079 | 0.73 | CYP1A2 (0.41) | CYP2C19CYP3A4ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL11216416 | 0.73 | ALDH1A1 (0.52) | CYP2C19CYP3A4ALDH1A1KDM4ECHRM3 | |
| SCHEMBL15077740 | 0.73 | CYP1A2 (0.41) | CYP2C19CYP3A4ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10271603 | 0.71 | ALDH1A1 (0.41) | CYP2C19CYP2D6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL17974909 | 0.71 | NR1H2 (0.44) | CYP2C19ALDH1A1CYP1A2CYP2C9TSHR | |
| SCHEMBL11214283 | 0.69 | ALDH1A1 (0.43) | CYP2C19CYP2D6CYP3A4ALDH1A1CHRM3 | |
| SCHEMBL31028964 | 0.68 | TAAR1 (0.41) | CYP2C19CYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL28142533 | 0.68 | ALDH1A1 (0.45) | CYP2C19CYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL27715318 | 0.68 | TAAR1 (0.41) | CYP2C19CYP3A4ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009805-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-11 | — | — | US | disclosed |
| WO-2016123391-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009805-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | TAF1, TAF1L, TAF1B | CYP2C19 3738/4885CYP2D6 2542/4885CYP3A4 4039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.