Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 12/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18024307 | 1.00 | PRKCZ (0.46) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18024308 | 0.84 | PRKCZ (0.50) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17981335 | 0.84 | PRKCZ (0.50) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL18024342 | 0.84 | PRKCZ (0.50) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17981095 | 0.82 | PRKCZ (0.62) | PRKCZ | |
| SCHEMBL17981380 | 0.77 | PIK3CD (0.46) | PRKCZCYP11B2 | |
| SCHEMBL17980981 | 0.71 | PRKCZ (0.48) | PRKCZKMT2APRKCQCCNT1CDK1 | |
| SCHEMBL18024551 | 0.71 | KMT2A (0.39) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17980982 | 0.71 | KMT2A (0.39) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL19762268 | 0.71 | KMT2A (0.43) | PRKCZCHRNB1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256217-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | Basilea Pharmaceutica International AG (CH) | 2017-12-20 | — | — | EP | disclosed |
| WO-2016128465-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | BASILEA PHARMACEUTICA AG (CH) | 2016-08-18 | — | — | WO | disclosed |