Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | STAT1 | P42224 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | NPY2R | P49146 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17963146 | 0.87 | GAA (0.67) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL17963068 | 0.84 | GAA (0.61) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL20418814 | 0.83 | LMNA (0.61) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL583369 | 0.82 | GAA (0.70) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL582277 | 0.79 | GAA (0.72) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL17963246 | 0.75 | GAA (0.60) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL17963296 | 0.75 | GAA (0.60) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL20418878 | 0.74 | GAA (0.58) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL20413735 | 0.74 | LMNA (0.49) | GAANPSR1LMNASMN1; SMN2STAT1 | |
| SCHEMBL17963372 | 0.73 | GAA (0.57) | GAANPSR1LMNASMN1; SMN2STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123392-A2 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-08-04 | — | — | WO | disclosed |