Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17987344 | 0.90 | KMT2A (0.43) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL17987347 | 0.84 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2APLA2G10PLA2G2A | |
| SCHEMBL20630144 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL20629759 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL17987307 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2APLA2G10PLA2G2A | |
| SCHEMBL17963584 | 0.74 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL17987125 | 0.72 | PLA2G10 (0.35) | ALDH1A1MEN1KMT2APLA2G10PLA2G2A | |
| SCHEMBL17987348 | 0.72 | PLA2G10 (0.35) | ALDH1A1MEN1KMT2APLA2G10PLA2G2A | |
| SCHEMBL17987122 | 0.71 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2APLA2G2AHPGD | |
| SCHEMBL17987305 | 0.71 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250569-B1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-09 | — | — | EP | disclosed |
| WO-2016123275-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-08-04 | — | — | WO | disclosed |