Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 5/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17988 | 1.00 | ACE (0.47) | ACEPTPN1CTSSCTSKSCN9A | |
| SCHEMBL18238 | 0.89 | SCN9A (0.41) | CTSSCTSKSCN9ACYP3A4SCN10A | |
| SCHEMBL18239 | 0.89 | SCN9A (0.41) | CTSSCTSKSCN9ACYP3A4SCN10A | |
| SCHEMBL30705546 | 0.81 | TACR1 (0.48) | ACECTSSCTSKSCN9ACYP3A4 | |
| SCHEMBL18154504 | 0.80 | ACE (0.69) | ACECTSSCTSKKLK5CTSL | |
| SCHEMBL10688353 | 0.80 | ACE (0.69) | ACECTSSCTSKKLK5CTSL | |
| SCHEMBL30487469 | 0.80 | ACE (0.69) | ACECTSSCTSKKLK5CTSL | |
| SCHEMBL30705643 | 0.80 | REN (0.46) | ACECTSSCTSKSCN9ACYP3A4 | |
| SCHEMBL18495333 | 0.78 | ACE (0.66) | ACEPTPN1CTSSCTSKKLK5 | |
| SCHEMBL11862942 | 0.78 | ACE (0.66) | ACEPTPN1CTSSCTSKKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |