Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 8/20 | 0.49 |
| ▸ | SGK1 | O00141 | 5/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.46 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.46 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15500885 | 0.92 | MAP3K11 (0.57) | AXLSGK1CAMKK2CDK8TNIK | |
| SCHEMBL1801878 | 0.91 | HTR2C (0.56) | AXLSGK1CAMKK2CDK8TNIK | |
| SCHEMBL1800577 | 0.91 | MAP3K11 (0.55) | AXLSGK1CAMKK2CDK8TNIK | |
| SCHEMBL4409012 | 0.86 | MAP4K1 (0.53) | TNIKMAP3K11 | |
| SCHEMBL15500866 | 0.86 | AXL (0.45) | AXLSGK1CAMKK2CDK8TNIK | |
| SCHEMBL1796715 | 0.85 | AXL (0.61) | AXLSGK1CAMKK2CDK8TNIK | |
| SCHEMBL1799492 | 0.84 | TNIK (0.40) | TNIKMAP3K11 | |
| SCHEMBL1798655 | 0.84 | CYP3A4 (0.44) | TNIKMAP3K11IGF1RAURKASGK2 | |
| SCHEMBL1799494 | 0.84 | TNIK (0.39) | TNIKMAP3K11 | |
| SCHEMBL4403894 | 0.81 | MAP4K1 (0.55) | TNIKMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951802-B2 | Use of 7-azaindoles in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |