Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.37 |
| ▸ | ATP4B | P51164 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801258 | 0.91 | MAP3K11 (0.46) | TNIKMAP3K11NTRK1 | |
| SCHEMBL1798276 | 0.91 | NTRK1 (0.47) | MAP3K11NTRK1HTR2CHPGDKIT | |
| SCHEMBL1801625 | 0.85 | AXL (0.40) | TNIKNTRK1CDK5CCNT1CCNA2 | |
| SCHEMBL1799165 | 0.84 | AXL (0.49) | TNIKMAP3K11 | |
| SCHEMBL1799492 | 0.81 | TNIK (0.40) | TNIKMAP3K11ATP4AATP4BNTRK1 | |
| SCHEMBL1798655 | 0.81 | CYP3A4 (0.44) | TNIKMAP3K11ATP4AATP4BNTRK1 | |
| SCHEMBL1799160 | 0.78 | HTR2C (0.38) | TNIKMAP3K11ATP4AATP4BNTRK1 | |
| SCHEMBL4409012 | 0.78 | MAP4K1 (0.53) | TNIKMAP3K11 | |
| SCHEMBL3347662 | 0.77 | ROCK1 (0.37) | TNIKMAP3K11ATP4AATP4BHTR2C | |
| SCHEMBL15500885 | 0.76 | MAP3K11 (0.57) | TNIKMAP3K11NTRK1CDK5CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951802-B2 | Use of 7-azaindoles in the inhibition of c-Jun N-terminal kinase | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |