Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15399203 | 0.80 | LMNA (0.62) | LMNAMAPTCA12CA2CA9 | |
| SCHEMBL2475367 | 0.75 | LMNA (0.72) | LMNAHTR6MAPTCA12CA2 | |
| SCHEMBL12489990 | 0.75 | LMNA (0.46) | LMNAMAPTCA2NPC1RAB9A | |
| SCHEMBL15398500 | 0.75 | LMNA (0.46) | LMNAMAPTCA2NPC1RAB9A | |
| SCHEMBL12490357 | 0.75 | STS (0.55) | LMNAMAPTCA2CA9NPC1 | |
| SCHEMBL15399135 | 0.75 | LMNA (0.46) | LMNAMAPTCA2NPC1RAB9A | |
| SCHEMBL17992004 | 0.69 | LMNA (0.54) | LMNAMAPTCA12CA2CA9 | |
| SCHEMBL12490830 | 0.68 | LMNA (0.54) | LMNAMAPTCA12CA2CA9 | |
| SCHEMBL15398657 | 0.68 | LMNA (0.62) | LMNAMAPTCA12CA2CA9 | |
| SCHEMBL15398562 | 0.68 | LMNA (0.41) | LMNAMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409859-B2 | Substituted diphenyl derivatives | CREATIVE THERAPEUTICS GMBH (DE) | 2016-08-09 | — | — | US | disclosed |