Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28427119 | 0.82 | ALDH1A1 (0.55) | HTTMAPTKMT2AGAAHPGD | |
| SCHEMBL21597725 | 0.78 | — | — | |
| SCHEMBL15296813 | 0.78 | — | — | |
| SCHEMBL17154475 | 0.76 | NAMPT (0.47) | HTTMAPTKMT2AGAAHPGD | |
| SCHEMBL12323193 | 0.74 | HDAC8 (0.67) | HTTMAPTGAAHPGDHDAC8 | |
| SCHEMBL20465768 | 0.73 | MAPT (0.63) | HTTMAPTKMT2ALMNA | |
| SCHEMBL28376355 | 0.72 | HDAC8 (0.64) | HTTMAPTGAAHPGDHDAC8 | |
| SCHEMBL12065915 | 0.72 | — | — | |
| SCHEMBL31185001 | 0.72 | MAPT (0.61) | HTTMAPTGAAHPGDHDAC8 | |
| SCHEMBL28509489 | 0.72 | ALDH1A1 (0.59) | HTTMAPTGAAHPGDHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |