Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 15/20 | 0.62 |
| ▸ | CHUK | O15111 | 11/20 | 0.62 |
| ▸ | CDK11B | P21127 | 2/20 | 0.62 |
| ▸ | CDK7 | P50613 | 2/20 | 0.62 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.62 |
| ▸ | MAP3K19 | Q56UN5 | 2/20 | 0.62 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.62 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.62 |
| ▸ | ERN1 | O75460 | 1/20 | 0.62 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | TYK2 | P29597 | 1/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.62 |
| ▸ | CDK9 | P50750 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.62 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.62 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bms-345541 SCHEMBL29670419 | 0.77 | IKBKB (1.00) | IKBKBCHUKCDK11BCDK7CDK13 | |
| Bms-345541 SCHEMBL118886 | 0.77 | IKBKB (1.00) | IKBKBCHUKCDK11BCDK7CDK13 | |
| Bms-345541 SCHEMBL14141907 | 0.76 | IKBKB (1.00) | IKBKBCHUKCDK11BCDK7CDK13 | |
| Bms-345541 SCHEMBL30120667 | 0.76 | IKBKB (1.00) | IKBKBCHUKCDK11BCDK7CDK13 | |
| SCHEMBL31069482 | 0.75 | IKBKB (0.59) | IKBKBCHUKCDK11BCDK7CDK13 | |
| SCHEMBL18344276 | 0.75 | IKBKB (0.59) | IKBKBCHUKCDK11BCDK7CDK13 | |
| SCHEMBL4981355 | 0.74 | IKBKB (0.66) | IKBKBCHUKCDK11BCDK7CDK13 | |
| Hydrochloric Acid SCHEMBL31069492 | 0.74 | IKBKB (0.60) | IKBKBCHUKCDK11BCDK7CDK13 | |
| SCHEMBL25735941 | 0.70 | IKBKB (0.80) | IKBKBCHUKCDK11BCDK7CDK13 | |
| SCHEMBL20440096 | 0.65 | BRD4 (0.69) | IKBKBCHUKCDK11BCDK7CDK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160228357-A1 | Auris Formulations for Treating Otic Diseases and Conditions | OTONOMY, INC. | 2016-08-11 | — | — | US | disclosed |
| US-20160228357-A1 | Auris Formulations for Treating Otic Diseases and Conditions | OTONOMY, INC. | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228357-A1 | Auris Formulations for Treating Otic Diseases and Conditions | OTC, AQP4, SLC26A4 | IKBKB 549/4885CHUK 1087/4885CDK11B 3732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.