Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 7/20 | 0.50 |
| ▸ | BRAF | P15056 | 8/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17997436 | 0.92 | ECE1 (0.51) | ECE1BRAFEGFRRETABL1 | |
| SCHEMBL17997461 | 0.92 | ECE1 (0.51) | ECE1BRAFEGFRRETABL1 | |
| SCHEMBL17997438 | 0.87 | ECE1 (0.55) | ECE1BRAFEGFRRETCDK8 | |
| SCHEMBL3805268 | 0.87 | ECE1 (0.57) | ECE1BRAFEGFRRETABL1 | |
| SCHEMBL17997440 | 0.84 | ECE1 (0.46) | ECE1BRAFEGFRRETABL1 | |
| SCHEMBL926408 | 0.84 | TNIK (0.52) | TNIKCDK8 | |
| SCHEMBL27829367 | 0.81 | TNIK (0.44) | BRAFTNIK | |
| SCHEMBL927457 | 0.80 | TNIK (0.49) | ECE1BRAFTNIKCDK8 | |
| SCHEMBL27829311 | 0.80 | CDK8 (0.45) | BRAFTNIKCDK8 | |
| SCHEMBL15300101 | 0.80 | ECE1 (0.45) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2235015-B1 | AZABICYCLIC CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2016-08-24 | — | — | EP | claimed |
| EP-2235015-B1 | AZABICYCLIC CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2016-08-24 | — | — | EP | disclosed |