Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.71 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29833468 | 0.84 | TGFBR1 (1.00) | TGFBR1TGFBR2BRAFMAPK13KDR | |
| SCHEMBL18005137 | 0.84 | TGFBR1 (1.00) | TGFBR1TGFBR2BRAFMAPK13KDR | |
| SCHEMBL18005346 | 0.83 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL29833445 | 0.83 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18005180 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18005294 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2BRAFMAPK13KDR | |
| SCHEMBL29833474 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2BRAFMAPK13KDR | |
| SCHEMBL29833412 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL29833454 | 0.80 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18005248 | 0.80 | TGFBR1 (1.00) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259264-A1 | GDF-8 INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2017-12-27 | — | — | EP | claimed |
| WO-2016133838-A1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2016-08-25 | — | — | WO | claimed |