Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | TYK2 | P29597 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GPX4 | P36969 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | PRKX | P51817 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4714406 | 0.99 | KDM4E (0.38) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL1803254 | 0.79 | JAK1 (0.60) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL4714306 | 0.78 | JAK1 (0.59) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL4715014 | 0.75 | MAP4K4 (0.58) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL4715433 | 0.74 | KDM4E (0.59) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL1801291 | 0.72 | JAK1 (0.57) | JAK1JAK2TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL4714401 | 0.71 | JAK1 (0.56) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL1662422 | 0.66 | DAO (0.48) | KDM4ETP53MAPK14PAK4PRKX | |
| SCHEMBL1802992 | 0.63 | HPGD (0.73) | KDM4EALDH1A1TP53HPGDHSD17B10 | |
| SCHEMBL13291388 | 0.56 | INPPL1 (0.35) | ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4680897-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1641454-B1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2008-10-01 | — | — | EP | claimed |
| US-7300943-B2 | GSK-3 inhibitors | PFIZER INC. (US) | 2007-11-27 | — | — | US | claimed |
| JP-2007516169-A | — | — | 2007-06-21 | — | — | JP | claimed |
| EP-1641454-A1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | Pfizer Products Inc. (US) | 2006-04-05 | — | — | EP | claimed |
| US-20050026946-A1 | GSK-3 inhibitors | PFIZER INC | 2005-02-03 | — | — | US | claimed |
| WO-2005000303-A1 | PYRAZOLO`3,4-B!PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-01-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026946-A1 | GSK-3 inhibitors | GSK3B, GSK3A, GSKIP | KDM4E 2004/4885ALDH1A1 1553/4885TP53 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.