Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | GPX4 | P36969 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.58 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4715433 | 0.77 | KDM4E (0.59) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| Hydrochloric Acid SCHEMBL4714406 | 0.74 | KDM4E (0.38) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| Hydrochloric Acid SCHEMBL4714306 | 0.73 | JAK1 (0.59) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL4715012 | 0.69 | JAK2 (0.60) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL4711494 | 0.65 | ALDH1A1 (0.43) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL1802992 | 0.57 | HPGD (0.73) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL20936728 | 0.57 | AR (0.42) | ALDH1A1KDM4EARLMNAPKM | |
| SCHEMBL31088779 | 0.57 | NOTUM (0.40) | MAP4K4PIM1GPX4GSK3BPIM3 | |
| SCHEMBL29437720 | 0.56 | AR (0.55) | ALDH1A1KDM4EARKMT2AADORA2A | |
| SCHEMBL11590712 | 0.56 | AR (0.55) | ALDH1A1KDM4EARKMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641454-B1 | PYRAZOLO[3,4-B]PYRIDIN-6-ONES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2008-10-01 | — | — | EP | disclosed |
| US-7300943-B2 | GSK-3 inhibitors | PFIZER INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-20050026946-A1 | GSK-3 inhibitors | PFIZER INC | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026946-A1 | GSK-3 inhibitors | GSK3B, GSK3A, GSKIP | MAP4K4 1004/4885PIM1 1530/4885GPX4 3476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.