Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | STK17B | O94768 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18013037 | 0.90 | EGFR (0.63) | EGFRKDRERBB2BRAFSRC | |
| SCHEMBL18012082 | 0.90 | EGFR (0.64) | EGFRKDRERBB2FBP1BRAF | |
| SCHEMBL18013035 | 0.85 | EGFR (0.63) | EGFRKDRERBB2BRAFSRC | |
| SCHEMBL18013062 | 0.85 | EGFR (0.63) | EGFRKDRERBB2BRAFSRC | |
| SCHEMBL18013036 | 0.85 | ERBB2 (0.57) | EGFRKDRERBB2RETFLT4 | |
| SCHEMBL18012092 | 0.82 | EGFR (0.69) | EGFRKDRERBB2BRAFSRC | |
| SCHEMBL19885294 | 0.81 | EGFR (0.65) | EGFRKDRERBB2BRAFSRC | |
| SCHEMBL18013033 | 0.81 | EGFR (0.69) | EGFRKDRFBP1SRCABL1 | |
| SCHEMBL18012090 | 0.80 | EGFR (0.78) | EGFRKDRERBB2BRAFSRC | |
| SCHEMBL19885293 | 0.78 | EGFR (0.65) | EGFRKDRERBB2BRAFSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123706-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |