Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.69 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012882 | 0.92 | FBP1 (0.69) | EGFRFBP1KDM4EMAPTMAPK1 | |
| SCHEMBL18012089 | 0.87 | EGFR (0.75) | EGFRFBP1KDM4EMAPTMAPK1 | |
| SCHEMBL18012883 | 0.87 | EGFR (0.71) | EGFRFBP1HDAC3KDRHDAC4 | |
| SCHEMBL18013032 | 0.86 | EGFR (0.66) | EGFRFBP1MAPTALDH1A1ABL1 | |
| SCHEMBL18012880 | 0.83 | ERBB2 (0.55) | EGFRCYP2D6KDR | |
| SCHEMBL18013052 | 0.81 | KDR (0.52) | EGFRKDRFGFR1FLT1 | |
| SCHEMBL18013034 | 0.81 | EGFR (0.59) | EGFRFBP1MAPTABL1SRC | |
| SCHEMBL5845413 | 0.79 | EGFR (0.72) | EGFRFBP1KDM4EMAPTMAPK1 | |
| SCHEMBL18012884 | 0.79 | EGFR (0.53) | EGFRABL1SRCABL2LCK | |
| SCHEMBL18012075 | 0.79 | FBP1 (0.72) | EGFRFBP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123706-A1 | NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-08-11 | — | — | WO | disclosed |