Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 10/20 | 0.61 |
| ▸ | SCN7A | Q01118 | 10/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.60 |
| ▸ | SCN1A | P35498 | 2/20 | 0.58 |
| ▸ | SCN4A | P35499 | 2/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.58 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.58 |
| ▸ | SCN2B | O60939 | 1/20 | 0.58 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28888121 | 1.00 | SCN5A (0.61) | SCN5ASCN7ASCN9ASCN1ASCN4A | |
| SCHEMBL18013371 | 0.94 | SCN5A (0.68) | SCN5ASCN7ASCN9ASCN1ASCN4A | |
| SCHEMBL18013328 | 0.92 | SCN9A (0.64) | SCN5ASCN9A | |
| SCHEMBL18013308 | 0.91 | SCN5A (0.59) | SCN5ASCN7ASCN9ASCN1ASCN4A | |
| SCHEMBL28386963 | 0.91 | SCN5A (0.59) | SCN5ASCN7ASCN9ASCN1ASCN4A | |
| SCHEMBL18013369 | 0.89 | SCN9A (0.54) | SCN5ASCN7ASCN9A | |
| SCHEMBL18013114 | 0.86 | SCN9A (0.65) | SCN5ASCN9A | |
| SCHEMBL18013112 | 0.85 | SCN9A (0.61) | SCN5ASCN9A | |
| SCHEMBL18013105 | 0.84 | SCN9A (0.62) | SCN5ASCN9A | |
| SCHEMBL18013117 | 0.84 | SCN9A (0.67) | SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406380-B | Heterocyclic substituted N-sulfonyl benzamide derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-107207430-B | Heterocyclic substituted N-sulfonyl benzamide derivative, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| WO-2016124139-A1 | HETEROCYCLIC-SUBSTITUTED N-SULFONYLBENZAMIDE DERIVATIVES, PREPARATION METHOD FOR DERIVATIVES, AND PHARMACEUTICAL USE OF DERIVATIVES | 上海海雁医药科技有限公司 | 2016-08-11 | — | — | WO | disclosed |