Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | GALK1 | P51570 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10000785 | 0.81 | SOS1 (0.69) | SOS1KMT2AMEN1L3MBTL1CD274 | |
| SCHEMBL10025530 | 0.81 | CYP2C19 (0.58) | SOS1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL282163 | 0.80 | SOS1 (0.66) | SOS1KMT2AMEN1L3MBTL1CD274 | |
| SCHEMBL18014745 | 0.78 | RPA1 (0.51) | SOS1KMT2AMEN1CD274ALDH1A1 | |
| SCHEMBL624093 | 0.78 | ALDH1A1 (0.65) | SOS1KMT2AMEN1L3MBTL1CD274 | |
| SCHEMBL13719297 | 0.77 | SOS1 (0.63) | SOS1KMT2AMEN1L3MBTL1CD274 | |
| SCHEMBL9980406 | 0.77 | SOS1 (0.54) | SOS1KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5043758 | 0.75 | ALDH1A1 (0.68) | SOS1KMT2AMEN1L3MBTL1CD274 | |
| SCHEMBL6400955 | 0.75 | SOS1 (0.60) | SOS1KMT2AMEN1L3MBTL1CD274 | |
| SCHEMBL5043750 | 0.74 | SOS1 (0.59) | SOS1KMT2AMEN1L3MBTL1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | SOS1 3326/4885KMT2A 3843/4885MEN1 3008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.