Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585202 | 0.81 | CCR1 (0.50) | CCR1PDE10A | |
| SCHEMBL18015810 | 0.80 | PARP1 (0.42) | CCR1PDE10AMAPTNPC1 | |
| SCHEMBL14094659 | 0.79 | FAAH (0.40) | CCR1PDE10ANPC1 | |
| SCHEMBL18014754 | 0.79 | MEN1 (0.33) | — | |
| SCHEMBL24254121 | 0.73 | CYP3A4 (0.32) | — | |
| SCHEMBL9186312 | 0.71 | CCR1 (0.61) | CCR1MAPT | |
| SCHEMBL31490208 | 0.71 | CCR1 (0.61) | CCR1MAPT | |
| SCHEMBL17921511 | 0.69 | CCR1 (0.55) | CCR1PDE10AMAPT | |
| SCHEMBL30578145 | 0.69 | CCR1 (0.55) | CCR1PDE10AMAPT | |
| SCHEMBL12776030 | 0.69 | PDE10A (0.41) | CCR1PDE10AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | CCR1 4832/4885PDE10A 1526/4885MAPT 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.