SCHEMBL18015486

SCHEMBL18015486

Cc1cc(-c2ccccc2)ncc1-c1ccccc1-c1cc(-c2ccccc2-c2ccc(-c3ccc4c(c3)C(C)(C)CCC4(C)C)nc2)cc(C2C=CC=CC2c2cnc(-c3ccccc3)cc2C)c1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
RARG P13631 6/20 0.37
RARB P10826 5/20 0.37
RXRA P19793 2/20 0.37
RARA P10276 5/20 0.34
LDHA P00338 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19794436 0.87 RARG (0.47) RARGRARBRXRARARALDHA
SCHEMBL19794437 0.77 LDHA (0.42) RARGRARBRXRARARALDHA
SCHEMBL18015536 0.76 RARG (0.56) RARGRARBRXRARARA
SCHEMBL18015375 0.75 LDHA (0.54) LDHA
SCHEMBL21125949 0.75 LDHA (0.54) LDHA
SCHEMBL18015491 0.75 LDHA (0.54) LDHA
SCHEMBL19794458 0.74 RARB (0.46) RARGRARBRXRARARALDHA
SCHEMBL19794375 0.74 RARG (0.40) RARGRARBRXRARARALDHA
SCHEMBL21202890 0.74 RARG (0.56) RARGRARBRXRARARA
SCHEMBL16998408 0.74 RARG (0.50) RARGRARBRXRARARALDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016124304-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2016-08-11 WO disclosed