SCHEMBL1801783

SCHEMBL1801783

O=c1ccn([C@@H]2O[C@H](COC3O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.78

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.78
SLC28A2 O43868 1/20 0.78
SLC29A1 Q99808 1/20 0.78
SLC28A3 Q9HAS3 1/20 0.78
P2RY2 P41231 10/20 0.68
P2RY6 Q15077 8/20 0.68
P2RY14 Q15391 7/20 0.68
P2RY4 P51582 5/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5494169 1.00 SLC28A1 (0.78) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL7189865 1.00 SLC28A1 (0.78) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL7183641 1.00 SLC28A1 (0.78) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL7573342 0.99 SLC28A1 (0.76) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL7575088 0.93 SLC28A1 (0.67) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL4956688 0.93 SLC28A1 (0.70) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL6464709 0.90 SLC28A1 (0.62) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
SCHEMBL4211565 0.90 SLC28A1 (0.69) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Uridine SCHEMBL30019440 0.88 SLC28A1 (0.95) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Uridine SCHEMBL2912983 0.88 SLC28A1 (1.00) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024082546-A1 METHOD FOR BIOSYNTHESIS OF ARABINONUCLEOSIDE BY ONE-POT METHOD, AND COMPOSITION 凯莱英生命科学技术(天津)有限公司 2024-04-25 WO claimed
CN-115279891-A Recombinant gene engineering bacterium for preparing nelarabine and application thereof 正大天晴药业集团股份有限公司 2022-11-01 CN claimed
CN-111879875-A Method for determining cytarabine and uridine arabinoside in blood plasma 武汉伯瑞恒医药科技有限公司 2020-11-03 CN claimed
WO-2005090370-A1 PHARMACOLOGICALLY ACTIVE AGENTS CONTAINING ESTERIFIED PHOSPHONATES AND METHODS FOR USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-09-29 WO claimed
WO-2024082546-A1 METHOD FOR BIOSYNTHESIS OF ARABINONUCLEOSIDE BY ONE-POT METHOD, AND COMPOSITION 凯莱英生命科学技术(天津)有限公司 2024-04-25 WO disclosed
WO-2024082545-A1 METHOD FOR ENZYMATIC SYNTHESIS OF NUCLEOSIDE CONTAINING PROTECTING GROUP, AND COMPOSITION 凯莱英生命科学技术(天津)有限公司 2024-04-25 WO disclosed
CN-115938482-A Method for screening key genes, metabolites and pathways of spinal cord injury based on multi-group association analysis 宁夏医科大学总医院 2023-04-07 CN disclosed
EP-3271468-B1 DEAMINATION OF ORGANOPHOSPHORUS-NUCLEOSIDES LABORATORIO TECNICO DE SEGURIDAD Y ESTANDARIZACION SL (ES) 2022-12-14 EP disclosed
CN-115279891-A Recombinant gene engineering bacterium for preparing nelarabine and application thereof 正大天晴药业集团股份有限公司 2022-11-01 CN disclosed
CN-107849594-B Deamination of organophosphorus nucleosides 科技学专业学院有限公司 2022-01-18 CN disclosed
CN-112552361-A Cytarabine crystal, cytarabine freeze-dried powder and freeze-drying method 瀚晖制药有限公司 2021-03-26 CN disclosed
CN-106929553-B Method for synthesizing vidarabine by enzyme method 上海鑫欣生物科技有限公司 2021-02-19 CN disclosed
WO-2011011710-A1 METHODS OF TREATING VIRAL INFECTIONS CHIMERIX, INC. (US) 2011-01-27 WO disclosed
US-20100136536-A1 Molecular Switches And Methods For Their Use JOHNSON & JOHNSON RESEARCH PTY. LIMITED (AU) 2010-06-03 US disclosed
US-20070231810-A1 Multicomponent nucleic acid enzymes and methods for their use SPEEDX PTY LTD (AU) 2007-10-04 US disclosed
CN-1583776-A Preparing method for cytarabine HAIZHENG PHARMACEUTICAL CO LTD (CN) 2005-02-23 CN disclosed
EP-0703787-A1 CELL GROWTH REGULATORS NYCOMED PHARMA AS (NO) 1996-04-03 EP disclosed
WO-1994027632-A1 CELL GROWTH REGULATORS NYCOMED PHARMA A/S (NO) 1994-12-08 WO disclosed
US-4017606-A CYTOSINE ARABINOSIDE AND HYDROGENATED PYRIMIDINE NUCLEOSIDES THE UPJOHN COMPANY (US) 1977-04-12 US disclosed
US-4017606-A CYTOSINE ARABINOSIDE AND HYDROGENATED PYRIMIDINE NUCLEOSIDES THE UPJOHN COMPANY (US) 1977-04-12 US disclosed