Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16647857 | 0.91 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL16634892 | 0.88 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL18018464 | 0.88 | TRPA1 (0.83) | TRPA1 | |
| SCHEMBL18017850 | 0.88 | TRPA1 (0.84) | TRPA1 | |
| SCHEMBL16647887 | 0.87 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL16634891 | 0.85 | TRPA1 (0.83) | TRPA1 | |
| SCHEMBL18017847 | 0.85 | TRPA1 (0.82) | TRPA1 | |
| SCHEMBL16635043 | 0.85 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL18047620 | 0.85 | TRPA1 (0.75) | TRPA1 | |
| SCHEMBL18018075 | 0.85 | TRPA1 (0.75) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016128529-A1 | 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-08-18 | — | — | WO | disclosed |