⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240386 | 0.96 | TSHR (0.33) | — | |
| SCHEMBL6245017 | 0.96 | TSHR (0.33) | — | |
| SCHEMBL4828336 | 0.96 | TSHR (0.33) | — | |
| SCHEMBL6246251 | 0.96 | TSHR (0.33) | — | |
| SCHEMBL179988 | 0.96 | — | — | |
| SCHEMBL3836831 | 0.96 | — | — | |
| SCHEMBL179880 | 0.96 | — | — | |
| SCHEMBL6243787 | 0.96 | TSHR (0.33) | — | |
| SCHEMBL180213 | 0.87 | — | — | |
| SCHEMBL28331672 | 0.87 | TSHR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2662 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115672295-B | Preparation and application of imine type column [5] arene modified silica gel chromatographic packing | 中国科学院兰州化学物理研究所 | 2023-12-15 | — | — | CN | claimed |
| CN-115672295-A | Preparation and application of imine column [5] arene modified silica gel chromatographic packing | 中国科学院兰州化学物理研究所 | 2023-02-03 | — | — | CN | claimed |
| CN-110938426-A | Method for preparing AgI quantum dots through supermolecular polymer network limitation | 西北师范大学 | 2020-03-31 | — | — | CN | claimed |
| CN-104710438-A | Spirocyclic compound for promoting generation of iPS cells, and preparation method and use thereof | SHANGHAI INST MATERIA MEDICA | 2015-06-17 | — | — | CN | claimed |
| US-6888022-B2 | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis | ATHENA NEUROSCIENCES, INC. (US) | 2005-05-03 | — | — | US | claimed |
| US-20030229024-A1 | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | AUDIA JAMES E (US) | 2003-12-11 | — | — | US | claimed |
| US-20030130188-A1 | Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | THORSETT EUGENE D (US) | 2003-07-10 | — | — | US | claimed |
| US-6476263-B1 | Compounds for inhibiting β-amyloid peptide release and/or its synthesis | ELAN PHARMACEUTICALS, INC. | 2002-11-05 | — | — | US | claimed |
| US-20020052322-A1 | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | ELAN PHARMACEUTICALS, INC. | 2002-05-02 | — | — | US | claimed |
| US-6211235-B1 | ALZHEIMERS DISEASE | ELAN PHARMACEUTICALS, INC. | 2001-04-03 | — | — | US | claimed |
| US-6191166-B1 | ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. | 2001-02-20 | — | — | US | claimed |
| CN-1253554-A | Heterocyclic compounds and their use for inhibiting 'beta'-amyloid peptide | ELAN MEDICINE CO (US) | 2000-05-17 | — | — | CN | claimed |
| CN-1238779-A | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | ELAN PHARM INC (US) | 1999-12-15 | — | — | CN | claimed |
| EP-0942924-A2 | METHODS AND COMPOUNDS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022494-A9 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | — | 1998-08-20 | — | — | WO | claimed |
| WO-1998022494-A2 | METHODS AND COMPOUNDS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | claimed |
| WO-2024146541-A1 | MACROCYCLIC COMPOUNDS AS USP1 INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2024-07-11 | — | — | WO | disclosed |
| EP-4396173-A1 | HERBICIDAL MALONAMIDES CONTAINING A CONDENSED RING SYSTEM | BASF SE (DE) | 2024-07-10 | — | — | EP | disclosed |
| US-4173630-A | N2 Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1979-11-06 | — | — | US | disclosed |
| US-4033960-A | CLEAVAGE OF A NITRILE WITH HYDROGEN SULFIDE | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-05 | — | — | US | disclosed |