Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252245 | 0.88 | GRIK1 (0.51) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6192793 | 0.87 | GRIK1 (0.50) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17510916 | 0.87 | GRIK1 (0.50) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL24252168 | 0.87 | GRIK1 (0.50) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4290341 | 0.87 | GRIK1 (0.50) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29015070 | 0.84 | TRPA1 (0.51) | KMT2ACYP2D6CYP2C9CYP2C19HPGD | |
| SCHEMBL28014450 | 0.84 | GRIK1 (0.57) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7319532 | 0.82 | MAPT (0.51) | KMT2ACYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL17979633 | 0.79 | GRIK1 (0.47) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7356540 | 0.79 | GRIK1 (0.47) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016128131-A1 | BETA-LACTONE INHIBITORS OF PHOSPHOLIPASE A2 AND USES THEREOF | NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS (GR) | 2016-08-18 | — | — | WO | disclosed |