SCHEMBL18023930

SCHEMBL18023930

C[C@H](Nc1cncc(-c2cccnc2)n1)c1cccc(NC(=O)c2cncc(C(F)(F)F)c2)c1

nearest known ligand 0.64

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 16/20 0.64
RPS6KB1 P23443 1/20 0.54
USP36 Q9P275 1/20 0.53
RET P07949 1/20 0.51
PDGFRB P09619 1/20 0.51
KIT P10721 1/20 0.51
SRC P12931 1/20 0.51
PDGFRA P16234 1/20 0.51
FLT1 P17948 1/20 0.51
FLT4 P35916 1/20 0.51
KDR P35968 1/20 0.51
FRK P42685 1/20 0.51
DDR1 Q08345 1/20 0.51
LDHA P00338 1/20 0.51
LDHB P07195 1/20 0.51
MEN1 O00255 1/20 0.50
TSHR P16473 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13339854 0.89 CSF1R (0.77) CSF1RRETPDGFRBKITSRC
SCHEMBL20100909 0.88 CSF1R (0.72) CSF1RRETPDGFRBKITSRC
SCHEMBL18023935 0.87 CSF1R (0.59) CSF1RKDRLDHALDHBMEN1
SCHEMBL20100905 0.86 CSF1R (0.68) CSF1RRPS6KB1USP36RETPDGFRB
SCHEMBL18023962 0.85 CSF1R (0.86) CSF1RRPS6KB1USP36RETPDGFRB
SCHEMBL13339849 0.84 CSF1R (0.75) CSF1RRETPDGFRBKITSRC
SCHEMBL13340361 0.84 CSF1R (0.73) CSF1RRPS6KB1RETPDGFRBKIT
SCHEMBL13340426 0.83 CSF1R (0.72) CSF1RRPS6KB1RETPDGFRBKIT
SCHEMBL19447191 0.83 CSF1R (0.71) CSF1RRPS6KB1USP36RETPDGFRB
SCHEMBL17954640 0.82 CSF1R (0.73) CSF1RRPS6KB1RETPDGFRBKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3054937-B1 SPRAY DRY FORMULATIONS PULMOKINE INC (US) 2023-07-26 EP disclosed
US-20160235742-A1 SPRAY DRY FORMULATIONS GILEAD SCIENCES, INC. 2016-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160235742-A1 SPRAY DRY FORMULATIONS FLT1, KDR, ERBB2 CSF1R 169/4885RPS6KB1 911/4885USP36 1697/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.