SCHEMBL18023935

SCHEMBL18023935

C[C@H](Nc1cncc(-c2cccnc2)n1)c1cccc(NC(=O)Nc2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 6/20 0.59
LDHA P00338 1/20 0.51
LDHB P07195 1/20 0.51
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
MAPT P10636 1/20 0.49
LMNA P02545 1/20 0.49
POLB P06746 1/20 0.49
HTT P42858 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
NTRK1 P04629 3/20 0.49
KDR P35968 2/20 0.48
IDH2 P48735 1/20 0.48
RAF1 P04049 1/20 0.48
BRAF P15056 1/20 0.48
TRPV1 Q8NER1 1/20 0.48
TSHR P16473 1/20 0.48
EGFR P00533 1/20 0.47
FGFR1 P11362 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18023933 0.87 CSF1R (0.58) CSF1RLDHALDHBKMT2ASMN1; SMN2
SCHEMBL18023930 0.87 CSF1R (0.64) CSF1RLDHALDHBMEN1KMT2A
SCHEMBL18023932 0.85 CSF1R (0.60) CSF1RLDHALDHBMEN1KMT2A
SCHEMBL13339854 0.82 CSF1R (0.77) CSF1RLDHALDHBHTTSMN1; SMN2
SCHEMBL13340361 0.81 CSF1R (0.73) CSF1RLDHALDHBMEN1KMT2A
SCHEMBL19447218 0.81 LDHA (0.56) CSF1RLDHALDHBKDRBRAF
SCHEMBL13340426 0.80 CSF1R (0.72) CSF1RLDHALDHBKDR
SCHEMBL17954640 0.79 CSF1R (0.73) CSF1RLDHALDHBKDR
SCHEMBL20100909 0.79 CSF1R (0.72) CSF1RLDHALDHBHTTKDR
SCHEMBL13340396 0.79 CSF1R (0.70) CSF1RLDHALDHBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3054937-B1 SPRAY DRY FORMULATIONS PULMOKINE INC (US) 2023-07-26 EP disclosed
US-20160235742-A1 SPRAY DRY FORMULATIONS GILEAD SCIENCES, INC. 2016-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160235742-A1 SPRAY DRY FORMULATIONS FLT1, KDR, ERBB2 CSF1R 169/4885LDHA 4402/4885LDHB 4104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.