Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GJB2 | P29033 | 1/20 | 0.40 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.40 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.40 |
| ▸ | LGALS4 | P56470 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | FGF1 | P05230 | 3/20 | 0.34 |
| ▸ | FGF2 | P09038 | 3/20 | 0.34 |
| ▸ | VEGFA | P15692 | 3/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15508127 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL17300175 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL18733215 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL15508089 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL18333048 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL17300176 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL16079127 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL18733408 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL12819629 | 1.00 | MAPK1 (0.44) | MAPK1GJB2LGALS8LGALS3LGALS4 | |
| SCHEMBL9547050 | 0.93 | MAPK1 (0.51) | MAPK1GJB2LGALS8LGALS3LGALS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701650-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-07-11 | — | — | US | disclosed |
| WO-2016134292-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | WO | disclosed |