Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16069727 | 0.84 | SOS1 (0.48) | ALDH1A1HPGDCYP3A4HTTNPC1 | |
| SCHEMBL18000485 | 0.81 | PLK1 (0.43) | ALDH1A1HPGDNPC1RAB9AKMT2A | |
| SCHEMBL30601557 | 0.79 | CYP3A4 (0.50) | ALDH1A1MAPK1HPGDCYP3A4USP2 | |
| SCHEMBL3922933 | 0.79 | CYP3A4 (0.50) | ALDH1A1MAPK1HPGDCYP3A4USP2 | |
| SCHEMBL4480739 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPK1HPGDCYP3A4USP2 | |
| SCHEMBL21318895 | 0.76 | ALDH1A1 (0.34) | ALDH1A1HPGDCYP3A4USP2SMN1; SMN2 | |
| SCHEMBL1652968 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MAPK1HPGDCYP3A4SMN1; SMN2 | |
| SCHEMBL7833873 | 0.74 | CYP3A4 (0.51) | ALDH1A1MAPK1HPGDCYP3A4USP2 | |
| SCHEMBL30601548 | 0.73 | ALDH1A1 (0.67) | ALDH1A1MAPK1HPGDCYP3A4HTT | |
| SCHEMBL898467 | 0.73 | ALDH1A1 (0.67) | ALDH1A1MAPK1HPGDCYP3A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170290839-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | INCYTE CORPORATION | 2017-10-12 | — | — | US | disclosed |
| US-9708318-B2 | Bicyclic heterocycles as FGFR4 inhibitors | INCYTE CORPORATION (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160244449-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | INCYTE CORPORATION | 2016-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290839-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | FGFR4, FGFR3, FGFR1 | ALDH1A1 1368/4885MAPK1 2247/4885HPGD 1519/4885 |
| US-20160244449-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | FGFR4, FGFR3, FGFR1 | ALDH1A1 1368/4885MAPK1 2247/4885HPGD 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.