Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 0.91 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.91 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.91 |
| ▸ | PGR | P06401 | 5/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.91 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.91 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.91 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.91 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.91 |
| ▸ | TNF | P01375 | 1/20 | 0.91 |
| ▸ | IL6 | P05231 | 1/20 | 0.91 |
| ▸ | AR | P10275 | 1/20 | 0.91 |
| ▸ | GLUL | P15104 | 1/20 | 0.91 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.91 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL5524347 | 0.99 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL28451307 | 0.96 | NR3C1 (0.91) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL5073648 | 0.96 | NR3C1 (0.98) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL503432 | 0.96 | NR3C1 (0.98) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL503431 | 0.96 | NR3C1 (0.98) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL5073644 | 0.96 | NR3C1 (0.98) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL23863778 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL6566835 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2597917 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL12396679 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11730697-B2 | Ocular drug delivery devices | BAUSCH HEALTH AMERICAS, INC. (US) | 2023-08-22 | — | — | US | claimed |
| US-20190133934-A1 | Ocular Drug Delivery Devices | ATON PHARMA, INC. (BM) | 2019-05-09 | — | — | US | claimed |
| EP-2493459-B1 | OCULAR DRUG DELIVERY DEVICES | ATON PHARMA INC (US) | 2016-08-24 | — | — | EP | claimed |
| US-20140187497-A1 | Ocular Drug Delivery Devices | LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-07-03 | — | — | US | claimed |
| EP-2493459-A1 | OCULAR DRUG DELIVERY DEVICES | Aton Pharma, Inc. (US) | 2012-09-05 | — | — | EP | claimed |
| US-20120213840-A1 | OCULAR STRIPS | VALEANT INTERNATIONAL (BARBADOS) SRL | 2012-08-23 | — | — | US | claimed |
| US-20120215184-A1 | CYLINDRICAL OCULAR INSERTS | VALEANT INTERNATIONAL (BARBADOS) SRL | 2012-08-23 | — | — | US | claimed |
| WO-2012112638-A1 | CROSS REFERENCE TO RELATED APPLICATIONS | VALEANT INTERNATIONAL (BARBADOS) SRL (BB) | 2012-08-23 | — | — | WO | claimed |
| WO-2012112636-A1 | CYLINDRICAL OCULAR INSERTS | VALEANT INTERNATIONAL (BARBADOS) SRL (BB) | 2012-08-23 | — | — | WO | claimed |
| US-20110129516-A1 | OCULAR DRUG DELIVERY DEVICES | ATON PHARMA, INC. | 2011-06-02 | — | — | US | claimed |
| WO-2011053841-A1 | OCULAR DRUG DELIVERY DEVICES | ATON PHARMA, INC. (US) | 2011-05-05 | — | — | WO | claimed |
| US-11730697-B2 | Ocular drug delivery devices | BAUSCH HEALTH AMERICAS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-20190133934-A1 | Ocular Drug Delivery Devices | ATON PHARMA, INC. (BM) | 2019-05-09 | — | — | US | disclosed |
| EP-2493459-B1 | OCULAR DRUG DELIVERY DEVICES | ATON PHARMA INC (US) | 2016-08-24 | — | — | EP | disclosed |
| US-20140187497-A1 | Ocular Drug Delivery Devices | LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-07-03 | — | — | US | disclosed |
| WO-2002058672-A2 | MICROPARTICLES OF BIODEGRADABLE POLYMER ENCAPSULATING A BIOLOGICALLY ACTIVE SUBSTANCE | DEBIO RECHERCHE PHARMACEUTIQUE S.A. (CH) | 2002-08-01 | — | — | WO | disclosed |
| WO-2002058671-A1 | BURST FREE PHARMACEUTICAL MICROPARTICULES | DEBIO RECHERCHE PHARMACEUTIQUE S.A. (CH) | 2002-08-01 | — | — | WO | disclosed |
| EP-1196148-A1 | PROCESS FOR MICROENCAPSULATION OF WATER SOLUBLE SUBSTANCES | Debio Recherche Pharmaceutique S.A. (CH) | 2002-04-17 | — | — | EP | disclosed |
| WO-2000062761-A1 | PROCESS FOR MICROENCAPSULATION OF WATER SOLUBLE SUBSTANCES | DEBIO RECHERCHE PHARMACEUTIQUE S.A. (CH) | 2000-10-26 | — | — | WO | disclosed |
| EP-1044683-A1 | One-step dispersion method for the microencapsulation of water soluble substances | DEBIO RECHERCHE PHARMACEUTIQUE S.A. (CH) | 2000-10-18 | — | — | EP | disclosed |