SCHEMBL18034818

COC(=O)c1ccc(-c2ccc(CC(NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N3C[Si](C)(C)C[C@H]3C(=O)N[C@@H]3CCCc4ccccc43)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	XIAP	P98170	20/20	0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16807557	1.00	XIAP (0.61)	XIAP
SCHEMBL17758139	1.00	XIAP (0.61)	XIAP
SCHEMBL15424984	1.00	XIAP (0.61)	XIAP
SCHEMBL16780528	0.95	XIAP (0.62)	XIAP
SCHEMBL16780531	0.95	XIAP (0.62)	XIAP
SCHEMBL16807553	0.95	XIAP (0.62)	XIAP
SCHEMBL15424901	0.94	XIAP (0.60)	XIAP
SCHEMBL16807558	0.94	XIAP (0.60)	XIAP
SCHEMBL16780757	0.94	XIAP (0.60)	XIAP
SCHEMBL16780579	0.94	XIAP (0.64)	XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2872521-B1	IAP ANTAGONISTS	BRISTOL MYERS SQUIBB CO (US)	2016-08-24	—	—	EP	disclosed