SCHEMBL18037686

SCHEMBL18037686

COc1cc(C2CC(=O)c3c(cc(O)c(C/C=C(\C)CCC=C(C)C)c3O)O2)cc(OC)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ELANE P08246 9/20 1.00
ALOX5 P09917 3/20 1.00
PTGS2 P35354 4/20 0.95
ACHE P22303 5/20 0.84
TP53 P04637 1/20 0.76
MDM2 Q00987 1/20 0.76
PLA2G1B P04054 1/20 0.65
CACNA1G O43497 1/20 0.62
CACNA1H O95180 1/20 0.62
ESR1 P03372 1/20 0.62
MAPT P10636 1/20 0.62
MAPK1 P28482 1/20 0.62
KMT2A Q03164 1/20 0.62
ATM Q13315 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
ABCG2 Q9UNQ0 1/20 0.61
PDCD1 Q15116 1/20 0.61
CD274 Q9NZQ7 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18037687 1.00 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL30637395 1.00 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL18061374 0.96 ELANE (0.92) ELANEALOX5PTGS2ACHETP53
SCHEMBL24075552 0.92 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL18061379 0.92 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL18037684 0.91 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL18037685 0.91 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL18061371 0.91 ELANE (0.88) ELANEALOX5PTGS2ACHETP53
SCHEMBL18061380 0.91 ELANE (1.00) ELANEALOX5PTGS2ACHETP53
SCHEMBL24075553 0.91 ELANE (1.00) ELANEALOX5PTGS2ACHETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 WO claimed
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 WO disclosed
US-10406136-B2 Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) 2019-09-10 US disclosed
US-10406136-B2 Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) 2019-09-10 US disclosed
US-20160250179-A1 COMPOSITION FOR SUPPRESSING NEURAMINIDASE ACTIVITY COMPRISING GERANYLATED FLAVONOID DERIVED FROM PAULOWNIA TOMENTOSA AS ACTIVE INGREDIENT INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) 2016-09-01 US disclosed
US-20160250179-A1 COMPOSITION FOR SUPPRESSING NEURAMINIDASE ACTIVITY COMPRISING GERANYLATED FLAVONOID DERIVED FROM PAULOWNIA TOMENTOSA AS ACTIVE INGREDIENT INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) 2016-09-01 US disclosed
US-20160250179-A1 COMPOSITION FOR SUPPRESSING NEURAMINIDASE ACTIVITY COMPRISING GERANYLATED FLAVONOID DERIVED FROM PAULOWNIA TOMENTOSA AS ACTIVE INGREDIENT INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY (KR) 2016-09-01 US disclosed
CN-105682672-A Composition for inhibiting neuraminidase activity comprising geranylflavone from paulownia tomentosa as active ingredient 庆尚大学校产学协力团 2016-06-15 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10406136-B2 Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient NEU2, NEU1, ENGASE ELANE 62/4885ALOX5 1376/4885PTGS2 829/4885
US-20160250179-A1 COMPOSITION FOR SUPPRESSING NEURAMINIDASE ACTIVITY COMPRISING GERANYLATED FLAVONOID DERIVED FROM PAULOWNIA TOMENTOSA AS ACTIVE INGREDIENT NEU2, NEU1, ENGASE ELANE 62/4885ALOX5 1376/4885PTGS2 829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.