Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 16/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18056353 | 0.95 | ROCK1 (0.73) | ROCK1ROCK2DYRK3CLK1CLK2 | |
| Trifluoroacetic Acid SCHEMBL18038146 | 0.87 | ROCK1 (0.62) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038296 | 0.86 | ROCK1 (0.70) | ROCK1ROCK2DYRK3CLK1CLK2 | |
| Trifluoroacetic Acid SCHEMBL18038166 | 0.85 | ROCK1 (0.62) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038239 | 0.84 | ROCK1 (0.66) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038129 | 0.83 | ROCK1 (0.71) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038250 | 0.82 | ROCK1 (0.65) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038295 | 0.81 | ROCK1 (0.61) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038151 | 0.81 | ROCK1 (0.72) | ROCK1ROCK2 | |
| SCHEMBL18056616 | 0.80 | ROCK1 (0.69) | ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262041-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | Lycera Corporation (US) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016138335-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2016-09-01 | — | — | WO | disclosed |