Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 13/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18056355 | 0.94 | ROCK1 (0.73) | ROCK1ROCK2NPC1JAK2RAB9A | |
| Trifluoroacetic Acid SCHEMBL18038237 | 0.88 | ROCK2 (0.68) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038146 | 0.87 | ROCK1 (0.62) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038129 | 0.85 | ROCK1 (0.71) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038296 | 0.84 | ROCK1 (0.70) | ROCK1ROCK2RAB9A | |
| Trifluoroacetic Acid SCHEMBL18038295 | 0.84 | ROCK1 (0.61) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038166 | 0.84 | ROCK1 (0.62) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038358 | 0.84 | ROCK1 (0.67) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038250 | 0.84 | ROCK1 (0.65) | ROCK1ROCK2 | |
| Trifluoroacetic Acid SCHEMBL18038151 | 0.83 | ROCK1 (0.72) | ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262041-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | Lycera Corporation (US) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016138335-A1 | INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2016-09-01 | — | — | WO | disclosed |