Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 18/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 16/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18009756 | 0.83 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL18009671 | 0.82 | PRMT5 (0.45) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18026301 | 0.82 | PRMT5 (0.45) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL13170765 | 0.77 | PRMT5 (0.47) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18026198 | 0.77 | PRMT5 (0.47) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009818 | 0.76 | PI4KA (0.58) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009834 | 0.76 | PI4KA (0.58) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009709 | 0.74 | PRMT5 (0.43) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18009882 | 0.72 | PRMT5 (0.42) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL18026297 | 0.71 | PI4KA (0.43) | PRMT5WDR77PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262057-A1 | SUBSTITUTED NUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Inc (US) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016135582-A1 | SUBSTITUTED NUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. (US) | 2016-09-01 | — | — | WO | disclosed |