Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 17/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | CARS1 | P49589 | 1/20 | 0.38 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040363 | 0.90 | MET (0.49) | METKDR | |
| SCHEMBL371039 | 0.88 | MET (0.51) | METKDREGFRGAKRIPK2 | |
| SCHEMBL18040365 | 0.87 | MET (0.64) | METKDRPDGFRB | |
| SCHEMBL18040358 | 0.86 | MET (0.48) | METKDREGFRPDGFRB | |
| SCHEMBL18040360 | 0.83 | MET (0.54) | METKDREGFRPDGFRBRIPK2 | |
| SCHEMBL18040371 | 0.82 | MET (0.47) | METKDR | |
| SCHEMBL10133775 | 0.77 | MET (0.50) | METKDR | |
| SCHEMBL368546 | 0.76 | MET (0.65) | METKDRPDGFRB | |
| SCHEMBL10133801 | 0.73 | MET (0.46) | METKDREGFR | |
| SCHEMBL10134550 | 0.72 | MET (0.67) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593462-B1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS | BETTA PHARMACEUTICALS CO LTD (CN) | 2016-09-07 | — | — | EP | claimed |