Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.58 |
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | IGF1R | P08069 | 6/20 | 0.52 |
| ▸ | INSR | P06213 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | AKT2 | P31751 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040368 | 0.90 | MET (0.49) | METKDRIGF1RINSRAURKA | |
| SCHEMBL370195 | 0.89 | MET (0.67) | METKDRIGF1RINSRAURKA | |
| SCHEMBL18040370 | 0.83 | MET (0.58) | METKDRLCKKITAXL | |
| SCHEMBL18040359 | 0.80 | MET (0.58) | METKDRIGF1RINSRAURKA | |
| SCHEMBL17745606 | 0.80 | MET (0.71) | METAXL | |
| SCHEMBL370073 | 0.79 | MET (0.53) | METKDRIGF1RINSRAURKA | |
| SCHEMBL18040360 | 0.79 | MET (0.54) | METKDRIGF1RINSRAURKA | |
| SCHEMBL17745592 | 0.78 | MET (0.80) | METAXL | |
| SCHEMBL10133667 | 0.78 | MET (0.67) | METKDRLCKKITAXL | |
| SCHEMBL368394 | 0.77 | MET (0.74) | METKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593462-B1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS | BETTA PHARMACEUTICALS CO LTD (CN) | 2016-09-07 | — | — | EP | claimed |