Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.82 |
| ▸ | GAA | P10253 | 8/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.82 |
| ▸ | LMNA | P02545 | 5/20 | 0.82 |
| ▸ | HPGD | P15428 | 3/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.82 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | PKM | P14618 | 4/20 | 0.81 |
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | HTT | P42858 | 4/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684657 | 0.99 | MAPT (0.84) | MAPTGAAALDH1A1KDM4ELMNA | |
| Bromide SCHEMBL18040788 | 0.91 | MAPT (0.98) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL1684711 | 0.90 | MAPT (1.00) | MAPTGAAALDH1A1KDM4ELMNA | |
| Bromide SCHEMBL18040682 | 0.90 | MAPT (0.79) | MAPTGAAALDH1A1KDM4ELMNA | |
| Bromide SCHEMBL18040748 | 0.89 | MAPT (0.82) | MAPTGAAALDH1A1KDM4ELMNA | |
| Bromide SCHEMBL3426202 | 0.89 | MAPT (0.82) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL12390656 | 0.89 | MAPT (1.00) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL1684531 | 0.88 | MAPT (0.80) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL1684579 | 0.88 | MAPT (0.84) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL12427000 | 0.88 | MAPT (0.84) | MAPTGAAALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3111956-B1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3111956-A1 | BMI 1 PROTEIN EXPRESSION MODULATORS | PTC Therapeutics, Inc. (US) | 2017-01-04 | — | — | EP | disclosed |
| EP-2306836-B1 | BMI-1 PROTEIN EXPRESSION MODULATORS | PTC THERAPEUTICS INC (US) | 2016-09-07 | — | — | EP | disclosed |