SCHEMBL1804323

SCHEMBL1804323

COC(=O)C1CC(C(=O)O)CC2(CCCC2)C1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.42
CHRNB2 P17787 2/20 0.37
CHRNA4 P43681 2/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA7 P36544 1/20 0.37
APLNR P35414 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.33
SLC6A4 P31645 1/20 0.33
ALDH1A1 P00352 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PPM1B O75688 1/20 0.32
PTPN1 P18031 1/20 0.32
PPP1CC P36873 1/20 0.32
POLB P06746 2/20 0.31
BRD4 O60885 1/20 0.31
TP53 P04637 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
BTK Q06187 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1804322 0.93 CHRNB2 (0.41) CYP2C19CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL29768055 0.83 SMN1; SMN2 (0.41) CYP2C19CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL21380508 0.81 CHRNB2 (0.39) CYP2C19CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL1651109 0.79 CHRNB2 (0.39) CYP2C19CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL25338412 0.77 CYP2C19 (0.65) CYP2C19CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL9960236 0.77 CHRNB2 (0.42) CYP2C19CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL25287945 0.77 CYP2C19 (0.70) CYP2C19APLNRSMN1; SMN2SLC6A4ALDH1A1
SCHEMBL9977777 0.77 SMN1; SMN2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL9977722 0.77 SMN1; SMN2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL9977775 0.77 SMN1; SMN2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2493304-A1 SPIROLACTAM DERIVATIVES AND USES OF SAME H. Lundbeck A/S (DK) 2012-09-05 EP disclosed
WO-2011053575-A1 SPIROLACTAM DERIVATIVES AND USES OF SAME H. LUNDBECK A/S (DK) 2011-05-05 WO disclosed