Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Inosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.67 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.67 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.67 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.67 |
| ▸ | GAPDH | P04406 | 1/20 | 0.67 |
| ▸ | STAT6 | P42226 | 1/20 | 0.67 |
| ▸ | PI4KA | P42356 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.67 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.67 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.67 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Inosine SCHEMBL4110068 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL18653532 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL12763613 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL330178 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL2229394 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL298755 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL2046912 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL15804 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL20138477 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 | |
| Inosine SCHEMBL6748954 | 0.91 | SLC29A1 (0.75) | SLC29A1MAPK1SMN1; SMN2DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268041-A1 | DOSING STRATEGIES FOR TARGETING EPCAM POSITIVE BLADDER CANCER | Viventia Bio Inc. (CA) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016145354-A1 | DOSING STRATEGIES FOR TARGETING EPCAM POSITIVE BLADDER CANCER | VIVENTIA BIO INC. (CA) | 2016-09-15 | — | — | WO | disclosed |