Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 13/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | VNN1 | O95497 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049006 | 0.87 | KDR (0.62) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL18048969 | 0.84 | VNN1 (0.51) | PDPK1KDM4EMAPTALDH1A1KMT2A | |
| SCHEMBL4163407 | 0.81 | PDPK1 (0.63) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL18070922 | 0.80 | KDM4E (0.62) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL15528705 | 0.79 | MEN1 (0.79) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL31362715 | 0.78 | KDR (0.79) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL1715643 | 0.78 | DHODH (0.63) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL18049049 | 0.78 | PDPK1 (0.65) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL18071001 | 0.77 | MAPT (0.65) | PDPK1KDRKDM4EMAPTGAA | |
| SCHEMBL7012858 | 0.77 | RPS6KB1 (0.64) | PDPK1KDRKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |