Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049049 | 0.87 | PDPK1 (0.65) | PDPK1KDRMAPTALDH1A1KDM4E | |
| SCHEMBL18070890 | 0.82 | KDR (0.57) | PDPK1KDRPTK2CXCR1CXCR2 | |
| SCHEMBL18049009 | 0.82 | PDPK1 (0.47) | PDPK1KDRPTK2CXCR1CXCR2 | |
| Hydrochloric Acid SCHEMBL18049005 | 0.81 | PDPK1 (0.46) | PDPK1KDRPTK2CXCR1CXCR2 | |
| SCHEMBL18071016 | 0.77 | KCNQ3 (0.45) | — | |
| SCHEMBL6103736 | 0.75 | KDM5B (0.76) | KDM5BMAPTKDM4EKMT2AP4HTM | |
| SCHEMBL18049040 | 0.74 | TUBB4A (0.64) | PDPK1KDRMAPTALDH1A1KDM4E | |
| SCHEMBL18048949 | 0.74 | KDR (0.84) | PDPK1KDRMAPTKDM4EMEN1 | |
| SCHEMBL18049008 | 0.73 | KDR (0.61) | PDPK1KDRMAPTALDH1A1KDM4E | |
| SCHEMBL18049839 | 0.73 | PDPK1 (0.63) | PDPK1KDRMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | claimed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |