Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | PRKACA | P17612 | 3/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.53 |
| ▸ | PLK1 | P53350 | 3/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10304368 | 0.89 | GSK3A (0.64) | GSK3AGSK3BFLT3JAK2PRKACA | |
| SCHEMBL27851301 | 0.89 | GSK3A (0.64) | GSK3AGSK3BFLT3JAK2PRKACA | |
| SCHEMBL8942746 | 0.87 | — | — | |
| SCHEMBL10304390 | 0.86 | — | — | |
| SCHEMBL19325116 | 0.85 | KMT2A (0.49) | GSK3AGSK3BFLT3JAK2PRKACA | |
| SCHEMBL10304567 | 0.85 | GSK3A (0.51) | GSK3AGSK3BFLT3JAK2PRKACA | |
| SCHEMBL10304147 | 0.84 | — | — | |
| SCHEMBL18306385 | 0.82 | GSK3A (0.50) | GSK3AGSK3BFLT3JAK2PRKACA | |
| SCHEMBL10304636 | 0.82 | CDC7 (0.59) | GSK3AGSK3BFLT3JAK2PRKACA | |
| SCHEMBL10304475 | 0.81 | GSK3A (0.55) | GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3141252-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Inc. (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2442809-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2016-08-31 | — | — | EP | disclosed |