Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617560 | 0.82 | GRIN2B (0.45) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL617505 | 0.81 | GRIN2B (0.57) | GRIN2BCYP2D6CYP2C9CYP3A4CA2 | |
| SCHEMBL620312 | 0.74 | GRIN2B (0.57) | GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL3166460 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL12124917 | 0.70 | GRIN2B (0.45) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL3933073 | 0.69 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL8550410 | 0.69 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL13547205 | 0.68 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL23706353 | 0.68 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL20135084 | 0.67 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197874-B1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2016-08-31 | — | — | EP | disclosed |