Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 3/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10172516 | 0.86 | ASPH (0.45) | ERN1TDO2PTGER4CCNT1 | |
| SCHEMBL27215891 | 0.83 | PTGER4 (0.40) | ERN1PTGER4CCNT1 | |
| SCHEMBL30911828 | 0.80 | SCN5A (0.36) | ERN1PTGER4CCNT1 | |
| SCHEMBL23335134 | 0.79 | KDM4E (0.48) | CHEK1CHEK2IGF1RPIM1PIM2 | |
| SCHEMBL18052232 | 0.78 | CHEK1 (0.61) | CHEK1ROCK2ROCK1CDC42BPBERN1 | |
| SCHEMBL620035 | 0.77 | GRIN2B (0.40) | — | |
| SCHEMBL23335251 | 0.76 | CHEK1 (0.51) | CHEK1CHEK2PIM1PIM2JAK2 | |
| SCHEMBL618166 | 0.75 | CHEK1 (0.43) | CHEK1CHEK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL18052241 | 0.74 | CHEK1 (0.48) | CHEK1CHEK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL23335330 | 0.74 | CHEK1 (0.52) | CHEK1CHEK2IGF1RPTGER4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197874-B1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2016-08-31 | — | — | EP | disclosed |