Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44733 | 0.89 | TRPA1 (0.43) | TRPA1PHGDHLMNAKMT2AMEN1 | |
| SCHEMBL18059216 | 0.89 | TRPA1 (0.40) | TRPA1PHGDHLMNAKMT2AMEN1 | |
| SCHEMBL45214 | 0.77 | SERPINE1 (0.47) | LMNAKMT2AMEN1HTTMAPT | |
| SCHEMBL45518 | 0.76 | MEN1 (0.44) | PHGDHLMNAKMT2AMEN1POLB | |
| SCHEMBL16691235 | 0.75 | ESRRA (0.42) | LMNAKMT2AMEN1POLBHTT | |
| SCHEMBL46581 | 0.75 | F10 (0.43) | TRPA1LMNAKMT2AMEN1HTT | |
| SCHEMBL44799 | 0.73 | PHGDH (0.46) | TRPA1PHGDHLMNAKMT2AMEN1 | |
| SCHEMBL47058 | 0.72 | F10 (0.42) | TRPA1LMNAKMT2AMEN1HTT | |
| SCHEMBL47072 | 0.72 | MEN1 (0.41) | TRPA1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10226260 | 0.72 | F10 (0.41) | TRPA1LMNAKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |